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dc.contributor.authorDumnoensun Pruksakornen_US
dc.contributor.authorAreerak Phanphaisarnen_US
dc.contributor.authorOlarn Arpornchayanonen_US
dc.contributor.authorNantawat Uttamoen_US
dc.contributor.authorTaninnit Leerapunen_US
dc.contributor.authorJongkolnee Settakornen_US
dc.date.accessioned2018-09-04T10:07:43Z-
dc.date.available2018-09-04T10:07:43Z-
dc.date.issued2015-12-01en_US
dc.identifier.issn1877783Xen_US
dc.identifier.issn18777821en_US
dc.identifier.other2-s2.0-84949754411en_US
dc.identifier.other10.1016/j.canep.2015.10.016en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84949754411&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/54100-
dc.description.abstract© 2015 Elsevier Ltd. Background: Osteosarcoma is a common and aggressive primary malignant bone tumor occurring in children and adolescents. It is one of the most aggressive human cancers and the most common cause of cancer-associated limb loss. As treatment in Thailand has produced a lower survival rate than in developed countries; therefore, this study identified survival rate and the poor prognostic factors of osteosarcoma in Northern Thailand. Methods: The retrospective cases of osteosarcoma, diagnosis between 1 January 1996 and 31 December 2013, were evaluated. Five and ten year overall survival rates were analyzed using time-to-event analysis. Potential prognostic factors were identified by multivariate regression analysis. Results: There were 208 newly diagnosed osteosarcomas during that period, and 144 cases met the criteria for analysis. The majority of the osteosarcoma cases (78.5%) were aged 0-24 years. The overall 5- and 10-year survival rates were 37.9% and 33.6%, respectively. Presence of metastasis at initial examination, delayed and against treatment co-operation, and axial skeletal location were identified as independent prognostic factors for survival, with hazard ratios of 4.3, 2.5 and 3.8, and 3.1, respectively. Conclusions: This osteosarcoma cohort had a relatively poor overall survival rate. The prognostic factors identified would play a critical role in modifying survival rates of osteosarcoma patients; as rapid disease recognition, a better treatment counselling, as well as improving of chemotherapeutic regimens were found to be important in improving the overall survival rate in Thailand.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleSurvival rate and prognostic factors of conventional osteosarcoma in Northern Thailand: A series from Chiang Mai University Hospitalen_US
dc.typeJournalen_US
article.title.sourcetitleCancer Epidemiologyen_US
article.volume39en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsBangkok Hospitalen_US
Appears in Collections:CMUL: Journal Articles

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