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dc.contributor.authorBoontharika Thapsukhonen_US
dc.contributor.authorDonraporn Daranarongen_US
dc.contributor.authorPuttinan Meepowpanen_US
dc.contributor.authorNuttee Sureeen_US
dc.contributor.authorRobert Molloyen_US
dc.contributor.authorKewalin Inthanonen_US
dc.contributor.authorWeerah Wongkhamen_US
dc.contributor.authorWinita Punyodomen_US
dc.description.abstractIn this study, for the first time, a biodegradable poly(L-lactide-co- ε-caprolactone), PLC 67:33 copolymer was developed for use as temporary scaffolds in reconstructive nerve surgery. The effect of the surface topology and pore architecture were studied on the biocompatibility for supporting the growth of human umbilical cord Whartons jelly-derived mesenchymal stem cells (hWJ-MSCs) and human neuroblastoma cells (hNBCs) as cell models. Porous PLC membranes were prepared by electrospinning and phase immersion precipitation with particulate leaching and nonporous PLC membranes were prepared by solvent casting. From the results, the porous PLC membranes can support hWJ-MSCs and hNBCs cells better than the nonporous PLC membrane, and the interconnected pore scaffold prepared by electrospinning exhibited a more significant supporting attachment of the cells than the open pore and nonporous membranes. We can consider that these electrospun PLC membranes with 3-D interconnecting fiber networks and a high porosity warrant a potential use as nerve guides in reconstructive nerve surgery. © 2014 Taylor & Francis.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectMaterials Scienceen_US
dc.titleEffect of topology of poly(L-lactide-co-ε-caprolactone) scaffolds on the response of cultured human umbilical cord Whartons jelly-derived mesenchymal stem cells and neuroblastoma cell linesen_US
article.title.sourcetitleJournal of Biomaterials Science, Polymer Editionen_US
article.volume25en_US Mai Universityen_US of Phayaoen_US
Appears in Collections:CMUL: Journal Articles

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