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dc.contributor.authorHong Jin Jeonen_US
dc.contributor.authorDaihui Pengen_US
dc.contributor.authorHong Choon Chuaen_US
dc.contributor.authorManit Srisurapanonten_US
dc.contributor.authorMaurizio Favaen_US
dc.contributor.authorJae Nam Baeen_US
dc.contributor.authorSung Man Changen_US
dc.contributor.authorJin Pyo Hongen_US
dc.date.accessioned2018-09-04T09:33:43Z-
dc.date.available2018-09-04T09:33:43Z-
dc.date.issued2013-06-01en_US
dc.identifier.issn15732517en_US
dc.identifier.issn01650327en_US
dc.identifier.other2-s2.0-84877693947en_US
dc.identifier.other10.1016/j.jad.2013.01.001en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84877693947&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/52859-
dc.description.abstractBackground: Suicide rates are higher in East-Asians than other populations, and especially high in Koreans. However, little is known about suicidality risk and melancholic features in Asian patients with major depressive disorder (MDD). Method: Drug-free MDD outpatients were included from 13 centers across five ethnicities consisting of Chinese (n=290), Korean (n=101), Thai (n=102), Indian (n=27), and Malay (n=27). All were interviewed using the Mini-International Neuropsychiatric Interview (M.I.N.I.), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Symptoms Checklist 90-Revised (SCL-90-R). Results: Of 547 subjects, 177 MDD patients showed melancholic features (32.4%). These melancholic MDD patients revealed significantly higher suicidality risk (p<0.0001), hostility (p=0.037), and severity of depression (p<0.0001) than those MDD patients without melancholic features. Suicidality risk was significantly higher in MDD with melancholic features than those without in subjects with lower hostility, whereas it showed no difference in higher hostility. Adjusted odds ratios of melancholic features and hostility for moderate to high suicidality risk were 1.79 (95% CI=1.15-2.79) and 2.45 (95% CI=1.37-4.38), after adjusting for age, sex, education years, and depression severity. Post-hoc analyses showed that suicidality risk was higher in Korean and Chinese than that of Thai, Indian and Malay in MDD subjects with melancholic features, although depression severity showed no significant differences among the ethnicities. Conclusions: Suicidality risk is associated with both melancholic features and hostility and it shows cross-ethnic differences in Asian MDD patients, independent of depression severity. © 2013 Elsevier B.V.en_US
dc.subjectMedicineen_US
dc.subjectPsychologyen_US
dc.titleMelancholic features and hostility are associated with suicidality risk in Asian patients with major depressive disorderen_US
dc.typeJournalen_US
article.title.sourcetitleJournal of Affective Disordersen_US
article.volume148en_US
article.stream.affiliationsSungKyunKwan University, School of Medicineen_US
article.stream.affiliationsMassachusetts General Hospitalen_US
article.stream.affiliationsShanghai Jiao Tong University School of Medicineen_US
article.stream.affiliationsSingapore Institute of Mental Healthen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsInha University, College of Medicineen_US
article.stream.affiliationsKyungpook National University, School of Medicineen_US
article.stream.affiliationsUlsan Universityen_US
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