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dc.contributor.authorPornsiri Pitchakarnen_US
dc.contributor.authorTeera Chewonarinen_US
dc.contributor.authorKumiko Ogawaen_US
dc.contributor.authorShugo Suzukien_US
dc.contributor.authorMakoto Asamotoen_US
dc.contributor.authorSatoru Takahashien_US
dc.contributor.authorTomoyuki Shiraien_US
dc.contributor.authorPornngarm Limtrakulen_US
dc.description.abstractPolyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers. However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human (PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays. The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells through action on protease activity.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleEllagic acid inhibits migration and invasion by prostate cancer cell linesen_US
article.title.sourcetitleAsian Pacific Journal of Cancer Preventionen_US
article.volume14en_US Mai Universityen_US City Universityen_US Institute of Health Sciences Tokyoen_US
Appears in Collections:CMUL: Journal Articles

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