Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/52192
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dc.contributor.authorSakorn Pornpraserten_US
dc.contributor.authorSiratcha Phanthongen_US
dc.date.accessioned2018-09-04T09:21:56Z-
dc.date.available2018-09-04T09:21:56Z-
dc.date.issued2013-11-13en_US
dc.identifier.issn1532432Xen_US
dc.identifier.issn03630269en_US
dc.identifier.other2-s2.0-84887218117en_US
dc.identifier.other10.3109/03630269.2013.819558en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887218117&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/52192-
dc.description.abstractThalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are genetic disorders that cause hemolytic anemia. In areas with high frequencies of both hematological disorders, coinheritance of G-6-PD deficiency with thalassemia can be found. Whether G-6-PD deficiency, coinherited with thalassemia, enhances severe anemia is still unclear. Hematological parameters between thalassemia carriers with G-6-PD deficiency and those without G-6-PD deficiency were compared. The G-6-PD deficiency was diagnosed in 410 blood samples from thalassemia patients using a fluorescent spot test. The levels of hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV) and Hb A2/Hb E [β26(B8)Glu→Lys; HBB: c.79G>A] were measured using an automated blood counter and high performance liquid chromatography (HPLC), respectively. The G-6-PD deficiency was found in 37 samples (9.02%). Mean levels of Hb, PCV, MCV and Hb A2/E were similar between the two groups. Thus, G-6-PD deficiency did not enhance red blood cell pathology or induce more anemic severity in thalassemia patients. © Informa Healthcare USA, Inc.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleAnemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiencyen_US
dc.typeJournalen_US
article.title.sourcetitleHemoglobinen_US
article.volume37en_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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