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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51406| Title: | Bioactive carbazole alkaloids from Clausena wallichii roots |
| Authors: | Wisanu Maneerat Thunwadee Ritthiwigrom Sarot Cheenpracha Trinop Promgool Kulsiri Yossathera Suwanna Deachathai Wong Phakhodee Surat Laphookhieo |
| Authors: | Wisanu Maneerat Thunwadee Ritthiwigrom Sarot Cheenpracha Trinop Promgool Kulsiri Yossathera Suwanna Deachathai Wong Phakhodee Surat Laphookhieo |
| Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics |
| Issue Date: | 27-Apr-2012 |
| Abstract: | Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 μM, respectively. © 2012 The American Chemical Society and American Society of Pharmacognosy. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860341545&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51406 |
| ISSN: | 15206025 01633864 |
| Appears in Collections: | CMUL: Journal Articles |
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