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dc.contributor.authorJiraporn Chuangbunyaten_US
dc.contributor.authorAphiwat Teerawutgulragen_US
dc.contributor.authorStephen G. Pyneen_US
dc.contributor.authorSaisunee Liawruangrathen_US
dc.contributor.authorBoonsom Liawruangrathen_US
dc.description.abstractThe essential oils extracted by hydrodistillation from the flowers and fruits of Lepisanthes rubiginosa (Roxb.) Leenh. were analyzed by capillary GC and GC-MS. The major components of the flower essential oil were nerolidol (34.8%), palmitic acid (13.2%) and farnesol (10.0%). For the fruit essential oil, palmitic acid (66.1%), myristic and (10.0%) and linoleic acid (5.5%) appeared to be the major constituents. Evaluation for in vitro anticancer activity of the essential oils was done against three human cancer cell lines (KB-Oral cavity cancer, MCF7 Breast cancer, NCI-H187 Small cell lung cancer). Only the flower essential oil exhibited anticancer activity against NCI-H187. Small cell lung cancer with the IC50of 43.90 μgmL-1. The flower essential oil also possessed antioxidant activity (ABTS method) with the % inhibition of 25.4%, whereas the fruit essential oil did not show anticancer activity and possessed low antioxidant activity with the % inhibition of 6.4%. The flower and fruit essential oils exhibited strong antimicrobial activity against Trichophyton mentagophyte and showed moderately activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleA comparative study of the essential oil from flowers and fruits of lepisanthes rubiginosa (Roxb.) Leenhen_US
article.title.sourcetitleActa Pharmaceutica Scienciaen_US
article.volume53en_US Mai Universityen_US of Wollongongen_US
Appears in Collections:CMUL: Journal Articles

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