Antimalarial, Anticancer, Antimicrobial Activities and Chemical Constituents of Essential oil from the Aerial Parts of Cyperus kyllingia Endl

Abstract

The chemical constituents of the essential oil from Cyperus kyllingia Endl. were analyzed by a GC, GC-MS. Twenty-three compounds were identified, accounting for 93.75% of the total oil that consisted mainly of oxygenated sesquiterpenes (53.52%), particularly sesquiterpene hydrocarbons (38.97%), and carboxylic acid (1.26%). The most representative compounds were α-cadinol (19.32%), caryophyllene oxide (12.17%), α-muurolol (11.58%), α-humulene (9.85%), and α-atlantone (6.07%). The oil showed significant activities against Plasmodium falcipalum (K1, multi drug resistant strain) and NCI-H187 (Small Cell Lung Cancer) with the IC50 values of 7.52 and 7.72 μg/mL, respectively. The oil exhibited highly active against Staphylococcus aureus ATCC25923 and moderately active against Escherichia coli ATCC25922, Pseudomonas aeruginosa ATCC27553, Aspergillus flavus and Candida albicans. © Published 04 15/2011 EISSN: 1307-6167.